Glial Derived Neurotrophic Factor Essay Example | Topics and Well Written Essays - 500 words

Glial Derived Neurotrophic Factor - Essay Example Glial Derived Neurotrophic Factor (GDNF) is a naturally occurring protein found in the brain and there is evidence that GDNF is necessary for normal neuromuscular development and survival. In 1994 Amgen Inc. acquired the patent for synthetic GDNF. After a series of animal trials and pre-clinical trials, Phase-I trials began in 2001-2002 in the UK and at the University of Kentucky. These trials showed significant improvement for the participants and researchers at Bristol UK remarked, "Within a couple of months, patients were noticing dramatic improvements in their ability to move". Similar results were reported from the Kentucky trials, which noted, "...there appeared to be bilateral improvements, including improved postural stability [...] evidence of improved affect and fine motor control and speed". GDNF appeared to be a promising breakthrough. Based on the previous favorable results, Amgen initiated Phase-II trials involving 34 patients in 2003. However, by 2004 GDNF had been shown to cause brain lesions in primate tests and Amgen immediately halted the testing. It was noted by researchers that the primates had been given a dose 10 times that of the human participants and there was overwhelming evidence that the lesions were caused by the sudden withdrawal of GDNF.

Job Application Essay Example | Topics and Well Written Essays - 1500 words

Job Application - Essay Example Another means that I process requests are the correspondence between PCDUO’s and other Customer Service. The bulk of the correspondences are requests for processing claims and reviewing and or verifying of claims if processed correctly. The tasks also involve me having to write sent back letters to an inquisitor regarding balance billing, letter of credible coverage, or explaining to a provider why a claim is either denied correctly or paid correctly, and to submit an appeal if it’s an appealable denial. Be it a correspondence in STELLENT or PCDUO, I would carefully analyze each requests and cross reference it to the CHAMPVA policy manual and CSC/CPD desk procedures to determine whether to do a send back letter to the inquisitor, or to have the claim reprocessed. If a claim needs to be reprocessed, I would place the request through the â€Å"reprocessing worksheet† to inform CPD why the claim was denied, how much to pay the provider, whether to over ride timely f iling because evidence exist of timely submission, and give the specific instructions on how to reprocess the claim. My dedication to effective communication speaks well during my tenure since all my written correspondence, not once did I received a send back letter from a Supervisor or a â€Å"reprocessing worksheet† from CDP due to inaccurate or incomplete data. I always make sure that I check the policy manual and or CSC/CPD desk procedures and reference it to my correspondence to ensure efficacy and factualness of my judgment. Another example wherein I used my written communication skills to obtain needed information to respond to inquiries and provide information was when I was on active duty as a Guardsman in the Air Force. Being part of the chain of command, I would respond to daily inquiries through email from senior commanders and from junior personnel that involves critical matters pertaining to deployments,